Human CCDC23/SVBP protein (Recombinant) (His-Tag) (STJP018983)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CCDC23/SVBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SVBP |
| Gene ID | 374969 |
| Uniprot ID | SVBP_HUMAN |
| Accession Number | NP_955374 |
| Immunogen | Human |
| Immunogen Region | 1-66aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSEFMDPPA RKEKTKVKES VSRVEKAKQK SAQQELKQRQ RAEIYALNRV MTELEQQQFD EFCKQMQPPG E |
Additional Info
| Function | Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation. |
| Protein Name | Small Vasohibin-Binding ProteinCoiled Coil Domain-Containing Protein 23 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmSecretedCytoskeletonDetected Both Intracellularly And ExtracellularlyWithin CellsLocalizes Mainly To The Apical Part Of The Cell |
| Alternative Protein Names | Small Vasohibin-Binding Protein proteinCoiled Coil Domain-Containing Protein 23 proteinSVBP proteinCCDC23 protein |
Information sourced from Uniprot.org