Human CBX5 protein (Recombinant) (His-Tag) (STJP017584)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CBX5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBX5 |
| Gene ID | 23468 |
| Uniprot ID | CBX5_HUMAN |
| Accession Number | NP_001120794 |
| Immunogen | Human |
| Immunogen Region | 1-191aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. Ubiquitinated. |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1. Required for the formation of the inner centromere. |
| Protein Name | Chromobox Protein Homolog 5Antigen P25Heterochromatin Protein 1 Homolog AlphaHp1 Alpha |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8953750Reactome: R-HSA-983231Reactome: R-HSA-9843940 |
| Cellular Localisation | NucleusChromosomeCentromereColocalizes With Hnrnpu In The NucleusComponent Of Centromeric And Pericentromeric HeterochromatinAssociates With Chromosomes During MitosisAssociates Specifically With Chromatin During Metaphase And AnaphaseLocalizes To Sites Of Dna Damage |
| Alternative Protein Names | Chromobox Protein Homolog 5 proteinAntigen P25 proteinHeterochromatin Protein 1 Homolog Alpha proteinHp1 Alpha proteinCBX5 proteinHP1A protein |
Information sourced from Uniprot.org