Human CBX3 protein (Recombinant) (N-His) (STJP005298)

Name: Human CBX3 protein (Recombinant) (N-His) (STJP005298)
SKU: STJP005298
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP005298

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Short Description	Recombinant-Human CBX3-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
Protein Name	Chromobox Protein Homolog 3 Hech Heterochromatin Protein 1 Homolog Gamma Hp1 Gamma Modifier 2 Protein
Database Links	Reactome: R-HSA-427389 Reactome: R-HSA-73772 Reactome: R-HSA-8953750
Cellular Localisation	Nucleus Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential)
Alternative Protein Names	Chromobox Protein Homolog 3 protein Hech protein Heterochromatin Protein 1 Homolog Gamma protein Hp1 Gamma protein Modifier 2 Protein protein CBX3 protein

Information sourced from Uniprot.org