Human Cathepsin S protein (Active Recombinant) (C-His) (STJP000955)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Cathepsin S Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln17-Ile331) of human Cathepsin S/CTSS (Accession #NP_004070.3) fused with an 8×His tag at the C-terminus.
General Information
| Short Description | Active Recombinant-Human Cathepsin S-C-His protein was developed in hek293 cells using the region Gln17-Ile331. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 50mM MES, 100mM NaCl, pH 6.5. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The specific activity is >1390 pmol/min/Mu g. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CTSS |
| Gene ID | 1520 |
| Uniprot ID | CATS_HUMAN |
| Immunogen | Recombinant Human Cathepsin S Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln17-Ile331) of human Cathepsin S/CTSS (Accession #NP_004070.3) fused with an 8×His tag at the C-terminus. |
| Immunogen Region | Gln17-Ile331 |
| Immunogen Sequence | QLHKDPTLDHHWHLWKKTYG KQYKEKNEEAVRRLIWEKNL KFVMLHNLEHSMGMHSYDLG MNHLGDMTSEEVMSLMSSLR VPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSC GACWAFSAVGALEAQLKLKT GKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNK GIDSDASYPYKAMDQKCQYD SKYRAATCSKYTELPYGRED VLKEAVANKGPVSVGVDAR |
Additional Info
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
| Protein Name | Cathepsin S |
| Database Links | Reactome: R-HSA-1236977Reactome: R-HSA-1474228Reactome: R-HSA-1679131Reactome: R-HSA-2022090Reactome: R-HSA-2132295Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeSecretedCytoplasmic VesiclePhagosome |
| Alternative Protein Names | Cathepsin S proteinCTSS protein |
Information sourced from Uniprot.org