| Tissue Specificity | Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
| Post Translational Modifications | The mature protease can process its own propeptide, but not that of other caspases. |
| Function | Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. |
| Protein Name | Caspase-2Casp-2Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2Nedd-2Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-205025Reactome: R-HSA-6803207 |
| Cellular Localisation | |
| Alternative Protein Names | Caspase-2 proteinCasp-2 proteinNeural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 proteinNedd-2 proteinProtease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 proteinCASP2 proteinICH1 proteinNEDD2 protein |
Information sourced from Uniprot.org
