Human CASP2 protein (Recombinant) (N-His) (STJP004717)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CASP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CASP2 |
| Gene ID | 835 |
| Uniprot ID | CASP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly334-Thr452 |
Additional Info
| Post Translational Modifications | The mature protease can process its own propeptide, but not that of other caspases. |
| Function | Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. Isoform 1: Acts as a positive regulator of apoptosis. Isoform 2: Acts as a negative regulator of apoptosis. Isoform 3: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. |
| Protein Name | Caspase-2Casp-2Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2Nedd-2Protease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-205025Reactome: R-HSA-6803207 |
| Cellular Localisation | |
| Alternative Protein Names | Caspase-2 proteinCasp-2 proteinNeural Precursor Cell Expressed Developmentally Down-Regulated Protein 2 proteinNedd-2 proteinProtease Ich-1 Cleaved Into - Caspase-2 Subunit P18 - Caspase-2 Subunit P13 - Caspase-2 Subunit P12 proteinCASP2 proteinICH1 proteinNEDD2 protein |
Information sourced from Uniprot.org