| Short Description : | Recombinant-Human Casein kinase 2 beta/CSNK2B-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.2M NaCl, 1mM DTT, 1mM EDTA |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CSNK2B |
| Gene ID: | 1460 |
| Uniprot ID: | CSK2B_HUMAN |
| Accession Number: | NP_001311 |
| Immunogen: | Human |
| Immunogen Region: | 1-215aa |
| Immunogen Sequence: | MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR |
| Post Translational Modifications | Phosphorylated by alpha subunit. |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling. (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Protein Name | Casein Kinase Ii Subunit BetaCk Ii BetaPhosvitinProtein G5a |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-201688Reactome: R-HSA-2514853Reactome: R-HSA-445144Reactome: R-HSA-6798695Reactome: R-HSA-6804756Reactome: R-HSA-6814122Reactome: R-HSA-8934903Reactome: R-HSA-8939243Reactome: R-HSA-8948751Reactome: R-HSA-9755511Reactome: R-HSA-9828806 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Casein Kinase Ii Subunit Beta proteinCk Ii Beta proteinPhosvitin proteinProtein G5a proteinCSNK2B proteinCK2N proteinG5A protein |
Information sourced from Uniprot.org
