SDS-PAGE gel of recombinant human Cardiac Troponin I3 TNNI3 protein under reducing conditions

Human Cardiac Troponin I3/TNNI3 protein (Recombinant) (His-Tag) (STJP019397)

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STJP019397
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Short Description :Recombinant-Human Cardiac Troponin I3/TNNI3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 30% Glycerol, 0.1M NaCl, 0.1mM PMSF, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:TNNI3
Gene ID:7137
Uniprot ID:TNNI3_HUMAN
Accession Number:NP_000354.4
Immunogen:Human
Immunogen Region:1-210aa
Immunogen Sequence:MADGSSD AAREPRPAPA PIRRRSSNYR AYATEPHAKK KSKISASRKL QLKTLLLQIA KQELEREAEE RRGEKGRALS TRCQPLELAG LGFAELQDLC RQLHARVDKV DEERYDIEAK VTKNITEIAD LTQKIFDLRG KFKRPTLRRV RISADAMMQA LLGARAKESL DLRAHLKQVK KEDTEKENRE VGDWRKNIDA LSGMEG
Post Translational Modifications Phosphorylated at Ser-42 and Ser-44 by PRKCE.phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Protein Name Troponin I - Cardiac Muscle
Cardiac Troponin I
Database Links Reactome: R-HSA-390522
Reactome: R-HSA-5578775
Cellular Localisation
Alternative Protein Names Troponin I - Cardiac Muscle protein
Cardiac Troponin I protein
TNNI3 protein
TNNC1 protein

Information sourced from Uniprot.org

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