Human Carbonyl reductase 3/CBR3 protein (Recombinant) (His-Tag) (STJP016488)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Carbonyl reductase 3/CBR3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR3 |
| Gene ID | 874 |
| Uniprot ID | CBR3_HUMAN |
| Accession Number | NP_001227 |
| Immunogen | Human |
| Immunogen Region | 1-277aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRIL |
Additional Info
| Tissue Specificity | Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. |
| Function | Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified. |
| Protein Name | Carbonyl Reductase Nadph 3Nadph-Dependent Carbonyl Reductase 3Quinone Reductase Cbr3Short Chain Dehydrogenase/Reductase Family 21c Member 2 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Carbonyl Reductase Nadph 3 proteinNadph-Dependent Carbonyl Reductase 3 proteinQuinone Reductase Cbr3 proteinShort Chain Dehydrogenase/Reductase Family 21c Member 2 proteinCBR3 proteinSDR21C2 protein |
Information sourced from Uniprot.org