Human CAMKK2 protein (Recombinant) (N-His) (STJP005870)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CAMKK2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CAMKK2 |
| Gene ID | 10645 |
| Uniprot ID | KKCC2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gly332 |
Additional Info
| Post Translational Modifications | Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2Cam-Kk 2Cam-Kinase Kinase 2Camkk 2Calcium/Calmodulin-Dependent Protein Kinase Kinase BetaCam-Kk BetaCam-Kinase Kinase BetaCamkk Beta |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229Reactome: R-HSA-9619483 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionNeuron ProjectionPredominantly Nuclear In Unstimulated CellsRelocalizes Into Cytoplasm And Neurites After Forskolin Induction |
| Alternative Protein Names | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 proteinCam-Kk 2 proteinCam-Kinase Kinase 2 proteinCamkk 2 proteinCalcium/Calmodulin-Dependent Protein Kinase Kinase Beta proteinCam-Kk Beta proteinCam-Kinase Kinase Beta proteinCamkk Beta proteinCAMKK2 proteinCAMKKB proteinKIAA0787 protein |
Information sourced from Uniprot.org