Human CAMK2N1 protein (Recombinant) (His-Tag) (STJP018666)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CAMK2N1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAMK2N1 |
| Gene ID | 55450 |
| Uniprot ID | CK2N1_HUMAN |
| Accession Number | NP_061054 |
| Immunogen | Human |
| Immunogen Region | 1-78aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSEVLPY GDEKLSPYGD GGDVGQIFSC RLQDTNNFFG AGQNKRPPKL GQIGRSKRVV IEDDRIDDVL KNMTDKAPPG V |
Additional Info
| Function | Potent and specific inhibitor of CaM-kinase II (CAMK2). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear. Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass. Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction. Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Ii Inhibitor 1Camkii Inhibitory Protein AlphaCamkiin-Alpha |
| Database Links | |
| Cellular Localisation | SynapseCell ProjectionDendritePostsynaptic Density |
| Alternative Protein Names | Calcium/Calmodulin-Dependent Protein Kinase Ii Inhibitor 1 proteinCamkii Inhibitory Protein Alpha proteinCamkiin-Alpha proteinCAMK2N1 protein |
Information sourced from Uniprot.org