| Short Description : | Recombinant-Human Calmodulin 2/CALM2-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 7.5) |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CALM2 |
| Gene ID: | 801/805/808 |
| Uniprot ID: | CALM2_HUMAN |
| Accession Number: | NP_001734 |
| Immunogen: | Human |
| Immunogen Region: | 1-149aa |
| Immunogen Sequence: | MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK |
| Post Translational Modifications | Ubiquitination results in a strongly decreased activity. Phosphorylation results in a decreased activity. |
| Function | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. |
| Protein Name | Calmodulin-2 |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-111933Reactome: R-HSA-111957Reactome: R-HSA-111997Reactome: R-HSA-114608Reactome: R-HSA-1445148Reactome: R-HSA-1474151Reactome: R-HSA-163615Reactome: R-HSA-180024Reactome: R-HSA-1855204Reactome: R-HSA-2025928Reactome: R-HSA-203615Reactome: R-HSA-2151201Reactome: R-HSA-2514859Reactome: R-HSA-2672351Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-438066Reactome: R-HSA-442720Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-445355Reactome: R-HSA-451308Reactome: R-HSA-5210891Reactome: R-HSA-5218920Reactome: R-HSA-5218921Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-70221Reactome: R-HSA-8876725Reactome: R-HSA-9009391Reactome: R-HSA-9022535Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9617324Reactome: R-HSA-9619229Reactome: R-HSA-9619483Reactome: R-HSA-9620244Reactome: R-HSA-9648002Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9664323Reactome: R-HSA-983695Reactome: R-HSA-9856530 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleMicrotubule Organizing CenterCentrosomeDistributed Throughout The Cell During InterphaseBut During Mitosis Becomes Dramatically Localized To The Spindle Poles And The Spindle Microtubules |
| Alternative Protein Names | Calmodulin-2 proteinCALM2 proteinCAM2 proteinCAMB protein |
Information sourced from Uniprot.org
