Human CALM1 protein (Recombinant) (N-His) (STJP003937)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CALM1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CALM1 |
| Gene ID | 801/805/808 |
| Uniprot ID | CALM1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala2-Lys149 |
Additional Info
| Function | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2. (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. |
| Protein Name | Calmodulin-1 |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-111933Reactome: R-HSA-111957Reactome: R-HSA-111997Reactome: R-HSA-114608Reactome: R-HSA-1445148Reactome: R-HSA-1474151Reactome: R-HSA-163615Reactome: R-HSA-180024Reactome: R-HSA-1855204Reactome: R-HSA-2025928Reactome: R-HSA-203615Reactome: R-HSA-2151201Reactome: R-HSA-2514859Reactome: R-HSA-2672351Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-438066Reactome: R-HSA-442720Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-445355Reactome: R-HSA-451308Reactome: R-HSA-5210891Reactome: R-HSA-5218920Reactome: R-HSA-5218921Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-70221Reactome: R-HSA-8876725Reactome: R-HSA-9009391Reactome: R-HSA-9022535Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9617324Reactome: R-HSA-9619229Reactome: R-HSA-9619483Reactome: R-HSA-9620244Reactome: R-HSA-9648002Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9664323Reactome: R-HSA-983695Reactome: R-HSA-9856530 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumFlagellumDistributed Throughout The Cell During InterphaseBut During Mitosis Becomes Dramatically Localized To The Spindle Poles And The Spindle Microtubules |
| Alternative Protein Names | Calmodulin-1 proteinCALM1 proteinCALM proteinCAM proteinCAM1 protein |
Information sourced from Uniprot.org