Human CALCRL protein (Recombinant) (N-His) (STJP005492)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CALCRL-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CALCRL |
| Gene ID | 10203 |
| Uniprot ID | CALRL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu23-Glu133 |
Additional Info
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. |
| Protein Name | Calcitonin Gene-Related Peptide Type 1 ReceptorCgrp Type 1 ReceptorCalcitonin Receptor-Like ReceptorCrlr |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Calcitonin Gene-Related Peptide Type 1 Receptor proteinCgrp Type 1 Receptor proteinCalcitonin Receptor-Like Receptor proteinCrlr proteinCALCRL proteinCGRPR protein |
Information sourced from Uniprot.org