Human CACNA2D2 protein (Recombinant) (N-His) (STJP010996)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CACNA2D2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CACNA2D2 |
| Gene ID | 9254 |
| Uniprot ID | CA2D2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp291-Leu469 |
Additional Info
| Post Translational Modifications | May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinColocalizes With Cacna1a In Lipid Raft Fractions |
| Alternative Protein Names | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 proteinVoltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 proteinCACNA2D2 proteinKIAA0558 protein |
Information sourced from Uniprot.org