Human CA125 (Mucin-16) Antibody Pair (STJAP00128)
General Information
| Short Description | This CA125 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A.Detection Purification: Protein A. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MUC16 |
| Gene ID | 94025 |
| Uniprot ID | MUC16_HUMAN |
| Immunogen | Capture immunogen: Native Protein.Detection Immunogen: Native Protein. |
Additional Info
| Post Translational Modifications | Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| Protein Name | Mucin-16Muc-16Ovarian Cancer-Related Tumor Marker Ca125Ca-125Ovarian Carcinoma Antigen Ca125 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceMay Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain |
| Alternative Antibody Pair Names | Mucin-16 antibody pairMuc-16 antibody pairOvarian Cancer-Related Tumor Marker Ca125 antibody pairCa-125 antibody pairOvarian Carcinoma Antigen Ca125 antibody pairMUC16 antibody pairCA125 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human CA125 (Mucin-16) Antibody Pair (STJAP00128)
This antibody pair detects human CA125, also known as Mucin-16 (UniProt Q8WXI7). Reactivity is confirmed for human samples only.
Both antibodies are mouse monoclonal antibodies supplied at 0.5 mg/mL. The capture antibody is unconjugated, and the detection antibody is biotinylated. Both were raised against the native protein immunogen and purified by Protein A.
This pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Both the capture and detection antibodies are formulated in PBS containing 0.04% Proclin 300 and 50% glycerol at pH 7.4.
Both components should be stored at -20°C for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.