Human C6 (Complement Component 6) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013982)
SPECIFICATIONS
General Information
| Short Description | This C6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.255ng/mL |
| Detection Limit | 0.625-40ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | C6 |
| Gene ID | 729 |
| Uniprot ID | CO6_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. |
| Function | Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending. |
| Protein Name | Complement Component C6 |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedTarget Cell MembraneMulti-Pass Membrane ProteinSecreted As Soluble ProteinInserts Into The Cell Membrane Of Target Cells |
| Alternative ELISA Names | Complement Component C6 ELISA kitC6 ELISA kit |
| output |
Information sourced from Uniprot.org