Human C2/Complement C2 protein (Recombinant-Active) (C-His) (STJP011808)

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STJP011808-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human C2/Complement C2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity: Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxyGly-ArgThioBenzyl ester (Z-GR-SBzl) , in the presence of 5, 5 Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is >35 pmol/min/µg, as measured under the
Gene Symbol: C2
Gene ID: 717
Uniprot ID: CO2_HUMAN
Immunogen Region: Ala21-Leu752
Immunogen: Homo sapiens (Human)
Function Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems. Serine protease complement C2b: Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex.
Protein Name Complement C2
C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b
Database Links Reactome: R-HSA-166663
Reactome: R-HSA-174577
Reactome: R-HSA-977606
Cellular Localisation Secreted
Cell Surface
Recruited To The Surface Of Pathogens By Complement C3b And Complement C4b Opsonins
Alternative Protein Names Complement C2 protein
C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b protein
C2 protein

Information sourced from Uniprot.org

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