Human C1QC protein (Recombinant) (N-6His & N-hFc) (STJP002008)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant HumanC1QC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn29-Asp245) of human ENPP-1 (Accession #P02747) fused with 6×His and hFc tag at the N-terminus.
General Information
| Short Description | Recombinant-Human C1QC-N-6His & N-hFc protein was developed in hek293 cells using the region Asn29-Asp245. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g |
Target Information
| Gene Symbol | C1QC |
| Gene ID | 714 |
| Uniprot ID | C1QC_HUMAN |
| Immunogen | Recombinant HumanC1QC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn29-Asp245) of human ENPP-1 (Accession #P02747) fused with 6×His and hFc tag at the N-terminus. |
| Immunogen Region | Asn29-Asp245 |
| Immunogen Sequence | NTGCYGIPGMPGLPGAPGKD GYDGLPGPKGEPGIPAIPGI RGPKGQKGEPGLPGHPGKNG PMGPPGMPGVPGPMGIPGEP GEEGRYKQKFQSVFTVTRQT HQPPAPNSLIRFNAVLTNPQ GDYDTSTGKFTCKVPGLYYF VYHASHTANLCVLLYRSGVK VVTFCGHTSKTNQVNSGGVL LRLQVGEEVWLAVNDYYDMV GIQGSDSVFSGFLLFPD |
Additional Info
| Function | Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system. |
| Protein Name | Complement C1q Subcomponent Subunit C |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceSpecifically Binds Igg Or Igm Immunoglobulins Complexed With AntigensForming Antigen-Antibody Complexes On The Surface Of Pathogens |
| Alternative Protein Names | Complement C1q Subcomponent Subunit C proteinC1QC proteinC1QG protein |
Information sourced from Uniprot.org