Human C1D protein (Recombinant) (His-Tag) (STJP018254)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human C1D-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C1D |
| Gene ID | 10438 |
| Uniprot ID | C1D_HUMAN |
| Accession Number | NP_775269 |
| Immunogen | Human |
| Immunogen Region | 1-141aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS |
Additional Info
| Tissue Specificity | Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal.lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. |
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
| Protein Name | Nuclear Nucleic Acid-Binding Protein C1dHc1d |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusCytoplasmNucleolusExosc10 Is Required For Nucleolar LocalizationColocalizes With Tsnax In The Nucleus |
| Alternative Protein Names | Nuclear Nucleic Acid-Binding Protein C1d proteinHc1d proteinC1D protein |
Information sourced from Uniprot.org