Human BTN3A1/CD277 protein (Recombinant) (C-hFc & His) (STJP002694)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant human BTN3A1/CD277 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln30-Gly254) of human BTN3A1/CD277 (Accession #NP_919423.1) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human BTN3A1/CD277-C-hFc & His protein was developed in hek293 cells using the region Gln30-Gly254. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its ability to inhibit Anti-CD3-induced proliferation of jurkat. The ED50 for this effect is 24-96 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BTN3A1 |
| Gene ID | 11119 |
| Uniprot ID | BT3A1_HUMAN |
| Immunogen | Recombinant human BTN3A1/CD277 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln30-Gly254) of human BTN3A1/CD277 (Accession #NP_919423.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Gln30-Gly254 |
| Immunogen Sequence | QFSVLGPSGPILAMVGEDAD LPCHLFPTMSAETMELKWVS SSLRQVVNVYADGKEVEDRQ SAPYRGRTSILRDGITAGKA ALRIHNVTASDSGKYLCYFQ DGDFYEKALVELKVAALGSD LHVDVKGYKDGGIHLECRST GWYPQPQIQWSNNKGENIPT VEAPVVADGVGLYAVAASVI MRGSSGEGVSCTIRSSLLGL EKTASISIADPFFRSAQRWI AALAG |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. |
| Protein Name | Butyrophilin Subfamily 3 Member A1Cd Antigen Cd277 |
| Database Links | Reactome: R-HSA-8851680 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Butyrophilin Subfamily 3 Member A1 proteinCd Antigen Cd277 proteinBTN3A1 proteinBTF5 protein |
Information sourced from Uniprot.org