Human BSND protein (Recombinant) (His-Tag) (STJP018310)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BSND-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BSND |
| Gene ID | 7809 |
| Uniprot ID | BSND_HUMAN |
| Accession Number | NP_476517 |
| Immunogen | Human |
| Immunogen Region | 54-320aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear. |
| Post Translational Modifications | Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels. |
| Function | Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing. Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates. |
| Protein Name | Barttin |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinMostly Sorted At The Basolateral MembraneA Significant Amount Also Observed IntracellularlyStaining In Membranes Of The Renal Tubule And Of Potassium-Secreting Epithelia Of The Inner Ear Is Basolateral |
| Alternative Protein Names | Barttin proteinBSND proteinBART protein |
Information sourced from Uniprot.org