Human BPNT1 protein (Recombinant) (His-Tag) (STJP017021)

Name: Human BPNT1 protein (Recombinant) (His-Tag) (STJP017021)
SKU: STJP017021
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017021

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Short Description	Recombinant-Human BPNT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 5mM DTT, 0.1M NaCl.
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	BPNT1
Gene ID	10380
Uniprot ID	BPNT1_HUMAN
Accession Number	NP_006076
Immunogen	Human
Immunogen Region	1-308aa
Immunogen Sequence	MASS NTVLMRLVAS AYSIAQKAGM IVRRVIAEGD LGIVEKTCAT DLQTKADRLA QMSICSSLAR KFPKLTIIGE EDLPSEEVDQ ELIEDSQWEE ILKQPCPSQY SAIKEEDLVV WVDPLDGTKE YTEGLLDNVT VLIGIAYEGK AIAGVINQPY YNYEAGPDAV LGRTIWGVLG LGAFGFQLKE VPAGKH

Tissue Specificity	Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.
Function	Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate. Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate.
Protein Name	3'(2' -5'-Bisphosphate Nucleotidase 1 3'-Phosphoadenosine 5'-Phosphate Phosphatase Pap Phosphatase Bisphosphate 3'-Nucleotidase 1 Bpntase 1 Hspip Inositol-Polyphosphate 1-Phosphatase
Database Links	Reactome: R-HSA-156584
Cellular Localisation
Alternative Protein Names	3'(2' -5'-Bisphosphate Nucleotidase 1 protein 3'-Phosphoadenosine 5'-Phosphate Phosphatase protein Pap Phosphatase protein Bisphosphate 3'-Nucleotidase 1 protein Bpntase 1 protein Hspip protein Inositol-Polyphosphate 1-Phosphatase protein BPNT1 protein

Information sourced from Uniprot.org