Human BPGM protein (Recombinant) (His-Tag) (STJP016667)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BPGM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BPGM |
| Gene ID | 669 |
| Uniprot ID | PMGE_HUMAN |
| Accession Number | NP_001715 |
| Immunogen | Human |
| Immunogen Region | 1-259aa |
| Immunogen Sequence | MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR EQMALNHGEE QVRLWRRSYN VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRA |
Additional Info
| Tissue Specificity | Expressed in red blood cells. Expressed in non-erythroid cells of the placenta.present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level). |
| Post Translational Modifications | Glycation of Lys-159 in diabetic patients inactivates the enzyme. |
| Function | Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase activity. |
| Protein Name | Bisphosphoglycerate MutaseBpgm2 -3-Bisphosphoglycerate Mutase - Erythrocyte2 -3-Bisphosphoglycerate Synthase2 -3-Diphosphoglycerate MutaseDpgmBpg-Dependent Pgam |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | |
| Alternative Protein Names | Bisphosphoglycerate Mutase proteinBpgm protein2 -3-Bisphosphoglycerate Mutase - Erythrocyte protein2 -3-Bisphosphoglycerate Synthase protein2 -3-Diphosphoglycerate Mutase proteinDpgm proteinBpg-Dependent Pgam proteinBPGM protein |
Information sourced from Uniprot.org