Human BMPR2 protein (Recombinant) (N-His) (STJP005365)

Name: Human BMPR2 protein (Recombinant) (N-His) (STJP005365)
SKU: STJP005365
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP005365

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Short Description	Recombinant-Human BMPR2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA.
Protein Name	Bone Morphogenetic Protein Receptor Type-2 Bmp Type-2 Receptor Bmpr-2 Bone Morphogenetic Protein Receptor Type Ii Bmp Type Ii Receptor Bmpr-Ii
Database Links	Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Bone Morphogenetic Protein Receptor Type-2 protein Bmp Type-2 Receptor protein Bmpr-2 protein Bone Morphogenetic Protein Receptor Type Ii protein Bmp Type Ii Receptor protein Bmpr-Ii protein BMPR2 protein PPH1 protein

Information sourced from Uniprot.org