Human BMPR2 (Bone Morphogenetic Protein Receptor Type-2) Antibody Pair (STJAP00182)
General Information
| Short Description | This BMPR2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A & Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | BMPR2 |
| Gene ID | 659 |
| Uniprot ID | BMPR2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human BMPR2 protein.Detection Immunogen: Recombinant Human BMPR2 protein. |
Additional Info
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-2Bmp Type-2 ReceptorBmpr-2Bone Morphogenetic Protein Receptor Type IiBmp Type Ii ReceptorBmpr-Ii |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Bone Morphogenetic Protein Receptor Type-2 antibody pairBmp Type-2 Receptor antibody pairBmpr-2 antibody pairBone Morphogenetic Protein Receptor Type Ii antibody pairBmp Type Ii Receptor antibody pairBmpr-Ii antibody pairBMPR2 antibody pairPPH1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human BMPR2 (Bone Morphogenetic Protein Receptor Type-2) Antibody Pair (STJAP00182)
This antibody pair detects human BMPR2 (Bone Morphogenetic Protein Receptor Type-2), corresponding to UniProt entry Q13873. Reactivity has been confirmed for human samples only.
The capture antibody is an unconjugated mouse monoclonal antibody, and the detection antibody is a biotin-conjugated rabbit polyclonal antibody. Both components are supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol, pH 7.4.
This pair has been validated for use in ELISA. No other assay formats are listed for this product.
The capture antibody was purified by Protein A or G, while the detection antibody was purified by both Protein A and antigen affinity purification. Both antibodies were raised against recombinant human BMPR2 protein as immunogen.
Both components should be stored at -20 degrees Celsius for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.