Human BMPR-1B/ALK-6 protein (Recombinant) (C-hFc&His) (STJP001235)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenActive Recombinant Human BMPR-1B/ALK-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys14-Arg126) of human BMPR-IB/ALK-6 (Accession #NP_001194.1) fused with a Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human BMPR-1B/ALK-6-C-hFc&His protein was developed in hek293 cells using the region Lys14-Arg126. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its binding ability in a functional ELISA. Immobilized Human BMP2 at 4 Mu g/mL (100 Mu L/well) can bind Human BMPRIB with a linear range of 20-338 ng/mL.|2.Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase producti |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BMPR1B |
| Gene ID | 658 |
| Uniprot ID | BMR1B_HUMAN |
| Immunogen | Active Recombinant Human BMPR-1B/ALK-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys14-Arg126) of human BMPR-IB/ALK-6 (Accession #NP_001194.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Lys14-Arg126 |
| Immunogen Sequence | KKEDGESTAPTPRPKVLRCK CHHHCPEDSVNNICSTDGYC FTMIEEDDSGLPVVTSGCLG LEGSDFQCRDTPIPHQRRSI ECCTERNECNKDLHPTLPPL KNRDFVDGPIHHR |
Additional Info
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-1bBmp Type-1b ReceptorBmpr-1bCd Antigen Cdw293 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Bone Morphogenetic Protein Receptor Type-1b proteinBmp Type-1b Receptor proteinBmpr-1b proteinCd Antigen Cdw293 proteinBMPR1B protein |
Information sourced from Uniprot.org