Human BMP-7 (monomer) protein (Recombinant) (His-Tag) (STJP019579)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BMP-7 (monomer)-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 10mM Sodium Citrate buffer (pH 3.5) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | BMP7 |
| Gene ID | 655 |
| Uniprot ID | BMP7_HUMAN |
| Accession Number | NP_001710.1 |
| Immunogen | Human |
| Immunogen Region | 293-431aa |
| Immunogen Sequence | MSTGSKQRSQ NRSKTPKNQE ALRMANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH |
Additional Info
| Tissue Specificity | Expressed in the kidney and bladder. Lower levels seen in the brain. |
| Post Translational Modifications | Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. |
| Function | Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. |
| Protein Name | Bone Morphogenetic Protein 7Bmp-7Osteogenic Protein 1Op-1Eptotermin Alfa |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-9844594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Bone Morphogenetic Protein 7 proteinBmp-7 proteinOsteogenic Protein 1 proteinOp-1 proteinEptotermin Alfa proteinBMP7 proteinOP1 protein |
Information sourced from Uniprot.org