| Post Translational Modifications | Autoubiquitinated and undergoes proteasome-mediated degradation. The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect. |
| Function | Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1: Blocks staurosporine-induced apoptosis. Promotes natural killer (NK) cell-mediated killing. Isoform 2: Blocks etoposide-induced apoptosis. Protects against natural killer (NK) cell-mediated killing. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 7Kidney Inhibitor Of Apoptosis ProteinKiapLivinMelanoma Inhibitor Of Apoptosis ProteinMl-IapRing Finger Protein 50Ring-Type E3 Ubiquitin Transferase Birc7 Cleaved Into - Baculoviral Iap Repeat-Containing Protein 7 30kda SubunitTruncated LivinP30-LivinTlivin |
| Database Links | Reactome: R-HSA-9824594 |
| Cellular Localisation | NucleusCytoplasmGolgi ApparatusNuclearAnd In A Filamentous Pattern Throughout The CytoplasmFull-Length Livin Is Detected Exclusively In The CytoplasmWhereas The Truncated Form (Tlivin) Is Found In The Peri-Nuclear Region With Marked Localization To The Golgi ApparatusThe Accumulation Of Tlivin In The Nucleus Shows Positive Correlation With The Increase In Apoptosis |
| Alternative Protein Names | Baculoviral Iap Repeat-Containing Protein 7 proteinKidney Inhibitor Of Apoptosis Protein proteinKiap proteinLivin proteinMelanoma Inhibitor Of Apoptosis Protein proteinMl-Iap proteinRing Finger Protein 50 proteinRing-Type E3 Ubiquitin Transferase Birc7 Cleaved Into - Baculoviral Iap Repeat-Containing Protein 7 30kda Subunit proteinTruncated Livin proteinP30-Livin proteinTlivin proteinBIRC7 proteinKIAP proteinLIVIN proteinMLIAP proteinRNF50 proteinUNQ5800 proteinPRO19607 proteinPRO21344 protein |
Information sourced from Uniprot.org
