Human BIN1 protein (Recombinant) (N-His) (STJP003158)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BIN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BIN1 |
| Gene ID | 274 |
| Uniprot ID | BIN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser276 |
Additional Info
| Post Translational Modifications | Phosphorylated by protein kinase C. |
| Function | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. |
| Protein Name | Myc Box-Dependent-Interacting Protein 1Amphiphysin IiAmphiphysin-Like ProteinBox-Dependent Myc-Interacting Protein 1Bridging Integrator 1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | Isoform Bin1: NucleusCytoplasmEndosomeCell MembraneSarcolemmaT-TubuleIsoform Iia: Cytoplasm |
| Alternative Protein Names | Myc Box-Dependent-Interacting Protein 1 proteinAmphiphysin Ii proteinAmphiphysin-Like Protein proteinBox-Dependent Myc-Interacting Protein 1 proteinBridging Integrator 1 proteinBIN1 proteinAMPHL protein |
Information sourced from Uniprot.org