Human BCL2L10 protein (Recombinant) (His-Tag) (STJP017964)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BCL2L10-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCL2L10 |
| Gene ID | 10017 |
| Uniprot ID | B2L10_HUMAN |
| Accession Number | NP_065129 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. |
| Post Translational Modifications | Monoubiquitinated by UBQLN1.results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. |
| Function | Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis. Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2. |
| Protein Name | Bcl-2-Like Protein 10Bcl2-L-10Anti-Apoptotic Protein BooAnti-Apoptotic Protein NrhApoptosis Regulator Bcl-B |
| Database Links | |
| Cellular Localisation | MitochondrionNucleus MembraneEndoplasmic ReticulumCytoplasmCytoskeletonSpindleLocalizes To Mitochondria-Associated Endoplasmic Reticulum Membranes (Mams)Localization To Mams Is Greatly Reduced Under Apoptotic Stress Conditions |
| Alternative Protein Names | Bcl-2-Like Protein 10 proteinBcl2-L-10 proteinAnti-Apoptotic Protein Boo proteinAnti-Apoptotic Protein Nrh proteinApoptosis Regulator Bcl-B proteinBCL2L10 proteinBCL-B proteinBCLB proteinBOO proteinDIVA protein |
Information sourced from Uniprot.org