Human BCL11A protein (Recombinant) (N-His) (STJP006373)

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STJP006373
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BCL11A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCL11A
Gene ID: 53335
Uniprot ID: BC11A_HUMAN
Immunogen Region: Met1-Arg210
Immunogen: Homo sapiens (Human)
Post Translational Modifications Sumoylated with SUMO1.
Function Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.
Protein Name B-Cell Lymphoma/Leukemia 11a
Bcl-11a
B-Cell Cll/Lymphoma 11a
Coup-Tf-Interacting Protein 1
Ecotropic Viral Integration Site 9 Protein Homolog
Evi-9
Zinc Finger Protein 856
Database Links Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Cellular Localisation Cytoplasm
Nucleus
Chromosome
Associates With The Nuclear Body
Colocalizes With Sumo1 And Senp2 In Nuclear Speckles
Isoform 1: Nucleus Matrix
Colocalizes With Bcl6 In Nuclear Paraspeckles
Isoform 2: Cytoplasm
Predominantly Localized In The Nucleus In Nuclear Paraspeckles
Isoform 3: Cytoplasm
Predominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2
In Presence Of Isoform 1 Or Isoform 2
Translocates From The Cytoplasm Into Nuclear Paraspeckles
Alternative Protein Names B-Cell Lymphoma/Leukemia 11a protein
Bcl-11a protein
B-Cell Cll/Lymphoma 11a protein
Coup-Tf-Interacting Protein 1 protein
Ecotropic Viral Integration Site 9 Protein Homolog protein
Evi-9 protein
Zinc Finger Protein 856 protein
BCL11A protein
CTIP1 protein
EVI9 protein
KIAA1809 protein
ZNF856 protein

Information sourced from Uniprot.org

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