Human BCL10 protein (Recombinant) (N-His) (STJP006552)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BCL10-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BCL10 |
| Gene ID | 8915 |
| Uniprot ID | BCL10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Gln233 |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP.linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP. Proteolytically cleaved by MALT1.required for T-cell activation. |
| Function | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors.CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. |
| Protein Name | B-Cell Lymphoma/Leukemia 10B-Cell Cll/Lymphoma 10Bcl-10Card-Containing Molecule Enhancing Nf-Kappa-BCard-Like Apoptotic ProteinHclapCed-3/Ich-1 Prodomain Homologous E10-Like RegulatorCiperCellular Homolog Of VcarmenCcarmenCellular-E10C-E10Mammalian Card-Containing Adapter Molecule E10Me10 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-5607764Reactome: R-HSA-8866654 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembrane RaftAppears To Have A PerinuclearCompact And Filamentous Pattern Of ExpressionAlso Found In The Nucleus Of Several Types Of Tumor CellsColocalized With Dpp4 In Membrane Rafts |
| Alternative Protein Names | B-Cell Lymphoma/Leukemia 10 proteinB-Cell Cll/Lymphoma 10 proteinBcl-10 proteinCard-Containing Molecule Enhancing Nf-Kappa-B proteinCard-Like Apoptotic Protein proteinHclap proteinCed-3/Ich-1 Prodomain Homologous E10-Like Regulator proteinCiper proteinCellular Homolog Of Vcarmen proteinCcarmen proteinCellular-E10 proteinC-E10 proteinMammalian Card-Containing Adapter Molecule E10 proteinMe10 proteinBCL10 proteinCIPER proteinCLAP protein |
Information sourced from Uniprot.org