Human Bcl-w protein (Recombinant) (His-Tag) (STJP016596)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Bcl-w-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCL2L2 |
| Gene ID | 599 |
| Uniprot ID | B2CL2_HUMAN |
| Accession Number | NP_004041 |
| Immunogen | Human |
| Immunogen Region | 1-172aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT |
Additional Info
| Tissue Specificity | Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. |
| Function | Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. |
| Protein Name | Bcl-2-Like Protein 2Bcl2-L-2Apoptosis Regulator Bcl-W |
| Database Links | |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinLoosely Associated With The Mitochondrial Membrane In Healthy CellsDuring ApoptosisTightly Bound To The Membrane |
| Alternative Protein Names | Bcl-2-Like Protein 2 proteinBcl2-L-2 proteinApoptosis Regulator Bcl-W proteinBCL2L2 proteinBCLW proteinKIAA0271 protein |
Information sourced from Uniprot.org