Human BCEI/PS2/TFF1 protein (Recombinant) (C-6His) (STJP002971)
SPECIFICATIONS
HostPichia
ConjugationUnconjugated
ImmunogenRecombinant Human BCEI/PS2/TFF1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu25-Phe84) of human BCEI/PS2/TFF1 (Accession #NP_003216.1) fused with and a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human BCEI/PS2/TFF1-C-6His protein was developed in pichia using the region Glu25-Phe84. For use in research applications. |
| Host | Pichia |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.001 EU/Mu g |
Target Information
| Gene Symbol | TFF1 |
| Gene ID | 7031 |
| Uniprot ID | TFF1_HUMAN |
| Immunogen | Recombinant Human BCEI/PS2/TFF1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu25-Phe84) of human BCEI/PS2/TFF1 (Accession #NP_003216.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Region | Glu25-Phe84 |
| Immunogen Sequence | VVASELRCQCLKTLPRVDFK NIQSLSVTPPGPHCAQTEVI ATLKGGQKVCLDPEAPLVQK IIQKILNKGKAN |
Additional Info
| Tissue Specificity | Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). |
| Function | Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. |
| Protein Name | Trefoil Factor 1Breast Cancer Estrogen-Inducible ProteinPnr-2Polypeptide P1.AHp1.AProtein Ps2 |
| Database Links | Reactome: R-HSA-9018519 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Trefoil Factor 1 proteinBreast Cancer Estrogen-Inducible Protein proteinPnr-2 proteinPolypeptide P1.A proteinHp1.A proteinProtein Ps2 proteinTFF1 proteinBCEI proteinPS2 protein |
Information sourced from Uniprot.org