Human BCCIP protein (Recombinant) (His-Tag) (STJP018844)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BCCIP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCCIP |
| Gene ID | 56647 |
| Uniprot ID | BCCIP_HUMAN |
| Accession Number | NP_510868 |
| Immunogen | Human |
| Immunogen Region | 1-314aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSEFMASRS KRRAVESGVP QPPDPPVQRD EEEEKEVENE DEDDDDSDKE KDEEDEVIDE EVNIEFEAYS LSDNDYDGIK KLLQQLFLKA PVNTAELTDL LIQQNHIGSV IKQTDVSEDS NDDMDEDEVF GFISLLNLTE RKGTQCVEQI QELVLRFCEK NCEKSMVEQL DKFLNDTTKP VGLLLSERFI NVPPQIALPM YQQLQKEL |
Additional Info
| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting ProteinP21- And Cdk-Associated Protein 1Protein Tok-1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindle PoleColocalizes With Brca2 In Discrete Nuclear FociIn InterphasePreferential Localizes To The Mother CentrioleRecruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin ActivityIsoform 1: CytoplasmIsoform 1/Beta Tends To Be Less Abundant AtAnd Less Strongly Associated WithCentrosomes Than Isoform 2/AlphaIsoform 2: CytoplasmIsoform 2/Alpha Tends To Be More Abundant AtAnd More Strongly Associated WithCentrosomes Than Isoform 1/Beta |
| Alternative Protein Names | Brca2 And Cdkn1a-Interacting Protein proteinP21- And Cdk-Associated Protein 1 proteinProtein Tok-1 proteinBCCIP proteinTOK1 protein |
Information sourced from Uniprot.org