Human BCAS3 protein (Recombinant) (N-His) (STJP006000)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BCAS3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BCAS3 |
| Gene ID | 54828 |
| Uniprot ID | BCAS3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met230-Gly546 |
Additional Info
| Function | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures. |
| Protein Name | Bcas3 Microtubule Associated Cell Migration FactorBreast Carcinoma-Amplified Sequence 3Gaob1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonPreautophagosomal StructureLocalizes In The Cytoplasm In Stationary CellsTranslocates From The Cytoplasm To The Leading Edge In Motile CellsColocalizes With Microtubules And Intermediate Filaments In Both Stationary And Motile CellsAssociates With ChromatinRecruited To Estrogen Receptor-Induced Promoters In A Pelp1-Dependent MannerThe Bcas3:Phaf1 Complex Is Recruited To The Preautophagosomal Structures Adjacent To The Damaged Mitochondria Upon Mitophagy In A Prkn-Pink1 Dependent Manner |
| Alternative Protein Names | Bcas3 Microtubule Associated Cell Migration Factor proteinBreast Carcinoma-Amplified Sequence 3 proteinGaob1 proteinBCAS3 protein |
Information sourced from Uniprot.org