Human BCAM/CD239 protein (Recombinant) (C-His) (STJP019892)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human BCAM/CD239 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu32-Ala547) of Human BCAM/CD239 (Accession #P50895) fused with a C-His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human BCAM/CD239-C-His protein was developed in hek293 cells using the region Glu32-Ala547. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BCAM |
| Gene ID | 4059 |
| Uniprot ID | BCAM_HUMAN |
| Immunogen | Recombinant Human BCAM/CD239 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu32-Ala547) of Human BCAM/CD239 (Accession #P50895) fused with a C-His tag at the C-terminus. |
| Immunogen Region | Glu32-Ala547 |
| Immunogen Sequence | EVRLSVPPLVEVMRGKSVIL DCTPTGTHDHYMLEWFLTDR SGARPRLASAEMQGSELQVT MHDTRGRSPPYQLDSQGRLV LAEAQVGDERDYVCVVRAGA AGTAEATARLNVFAKPEATE VSPNKGTLSVMEDSAQEIAT CNSRNGNPAPKITWYRNGQR LEVPVEMNPEGYMTSRTVRE ASGLLSLTSTLYLRLRKDDR DASFHCAAHYSLPEGRHGRL DSPTFHLTLHYPTEHVQFW |
Additional Info
| Tissue Specificity | Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. |
| Post Translational Modifications | Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1. |
| Function | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. |
| Protein Name | Basal Cell Adhesion MoleculeAuberger B AntigenB-Cam Cell Surface GlycoproteinF8/G253 AntigenLutheran AntigenLutheran Blood Group GlycoproteinCd Antigen Cd239 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Basal Cell Adhesion Molecule proteinAuberger B Antigen proteinB-Cam Cell Surface GlycoproteinF8/G253 Antigen proteinLutheran Antigen proteinLutheran Blood Group GlycoproteinCd Antigen Cd239 proteinBCAM proteinLU proteinMSK19 protein |
Information sourced from Uniprot.org