Human BAI1 (Brain Specific Angiogenesis Inhibitor 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013803)
SPECIFICATIONS
General Information
| Short Description | This BAI1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.065ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | ADGRB1 |
| Gene ID | 575 |
| Uniprot ID | AGRB1_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in brain (at protein level). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue. Reduced or no expression is observed in some glioblastomas. |
| Post Translational Modifications | Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated. |
| Function | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma. Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner. Vasculostatin-40: Inhibits angiogenesis. |
| Protein Name | Adhesion G Protein-Coupled Receptor B1Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40Vstat40 - Vasculostatin-120Vstat120 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionPhagocytic CupCell JunctionFocal AdhesionDendritic SpinePostsynaptic DensityVasculostatin-120: SecretedVasculostatin-40: Secreted |
| Alternative ELISA Names | Adhesion G Protein-Coupled Receptor B1 ELISA kitBrain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40 ELISA kitVstat40 - Vasculostatin-120 ELISA kitVstat120 ELISA kitADGRB1 ELISA kitBAI1 ELISA kit |
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Information sourced from Uniprot.org