Human BAG5 protein (Recombinant) (N-His) (STJP006365)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BAG5-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BAG5 |
| Gene ID | 9529 |
| Uniprot ID | BAG5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp248 |
Additional Info
| Function | Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. |
| Protein Name | Bag Family Molecular Chaperone Regulator 5Bag-5Bcl-2-Associated Athanogene 5 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | In CardiomyocytesLocalized At Specialized Membrane Contact Sites Between T-Tubules And The Sarcoplasmic ReticulumKnown As Junctional Membrane Complexes |
| Alternative Protein Names | Bag Family Molecular Chaperone Regulator 5 proteinBag-5 proteinBcl-2-Associated Athanogene 5 proteinBAG5 proteinKIAA0873 protein |
Information sourced from Uniprot.org