Human BACE2 protein (Recombinant) (N-His) (STJP006720)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BACE2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BACE2 |
| Gene ID | 25825 |
| Uniprot ID | BACE2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met230-Phe396 |
Additional Info
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Protein Names | Beta-Secretase 2 proteinAspartic-Like Protease 56 Kda proteinAspartyl Protease 1 proteinAsp1 proteinAsp 1 proteinBeta-Site Amyloid Precursor Protein Cleaving Enzyme 2 proteinBeta-Site App Cleaving Enzyme 2 proteinDown Region Aspartic Protease proteinDrap proteinMemapsin-1 proteinMembrane-Associated Aspartic Protease 1 proteinTheta-Secretase proteinBACE2 proteinAEPLC proteinALP56 proteinASP21 proteinCDA13 proteinUNQ418 proteinPRO852 protein |
Information sourced from Uniprot.org