| Short Description : | Recombinant-Human B7-H7/HHLA2-C-hFc protein was developed in hek293 cells using the region Ile23-Asn344. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | HHLA2 |
| Gene ID: | 11148 |
| Uniprot ID: | HHLA2_HUMAN |
| Immunogen: | Recombinant Human B7-H7/HHLA2 Protein is expressed from Expi293 with hFc tag at the C-terminal.；It contains Ile23-Asn344. |
| Immunogen Region: | Ile23-Asn344 |
| Immunogen Sequence: | IFPLAFFIYVPMNEQIVIGR LDEDIILPSSFERGSEVVIH WKYQDSYKVHSYYKGSDHLE SQDPRYANRTSLFYNEIQNG NASLFFRRVSLLDEGIYTCY VGTAIQVITNKVVLKVGVFL TPVMKYEKRNTNSFLICSVL SVYPRPIITWKMDNTPISEN NMEETGSLDSFSINSPLNIT GSNSSYECTIENSLLKQTWT GRWTMKDGLHKMQSEHVSLS CQPVNDYFSPNQDFKVTWS |
| Tissue Specificity | Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells. |
| Function | Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. |
| Protein Name | Herv-H Ltr-Associating Protein 2Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Herv-H Ltr-Associating Protein 2 proteinHuman Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 proteinHHLA2 protein |
Information sourced from Uniprot.org