Human B7-H5/Gi24/VISTA protein (Recombinant) (C-hFc) (STJP019818)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala194) of Human B7-H5/Gi24/VISTA (Accession #Q9H7M9) fused with a C-hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human B7-H5/Gi24/VISTA-C-hFc protein was developed in hek293 cells using the region Phe33-Ala194. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | VSIR |
| Gene ID | 64115 |
| Uniprot ID | VISTA_HUMAN |
| Immunogen | Recombinant Human B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala194) of Human B7-H5/Gi24/VISTA (Accession #Q9H7M9) fused with a C-hFc tag at the C-terminus. |
| Immunogen Region | Phe33-Ala194 |
| Immunogen Sequence | FKVATPYSLYVCPEGQNVTL TCRLLGPVDKGHDVTFYKTW YRSSRGEVQTCSERRPIRNL TFQDLHLHHGGHQAANTSHD LAQRHGLESASDHHGNFSIT MRNLTLLDSGLYCCLVVEIR HHHSEHRVHGAMELQVQTGK DAPSNCVVYPSSSQDSENIT AA |
Additional Info
| Tissue Specificity | Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues. |
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24Stress-Induced Secreted Protein-1Sisp-1V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation proteinPlatelet Receptor Gi24 proteinStress-Induced Secreted Protein-1 proteinSisp-1 proteinV-Set Domain-Containing Immunoregulatory Receptor proteinV-Set Immunoregulatory Receptor proteinVSIR proteinC10orf54 proteinSISP1 proteinVISTA proteinPP2135 proteinUNQ730 proteinPRO1412 protein |
Information sourced from Uniprot.org