Human B7-H3 (4Ig) /B7-H3b/CD276 protein (Recombinant) (C-hFc) (STJP019927)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human B7-H3 (4Ig) /B7-H3b/CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly27-Thr461) of Human B7-H3 (4Ig) /B7-H3b/CD276 (Accession #Q5ZPR3-1) fused with a C-hFc tag at the C-t
General Information
| Short Description | Recombinant-Human B7-H3 (4Ig) /B7-H3b/CD276-C-hFc protein was developed in hek293 cells using the region Gly27-Thr461. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD276 |
| Gene ID | 80381 |
| Uniprot ID | CD276_HUMAN |
| Immunogen | Recombinant Human B7-H3 (4Ig) /B7-H3b/CD276 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly27-Thr461) of Human B7-H3 (4Ig) /B7-H3b/CD276 (Accession #Q5ZPR3-1) fused with a C-hFc tag at the C-t |
| Immunogen Region | Gly27-Thr461 |
| Immunogen Sequence | GALEVQVPEDPVVALVGTDA TLCCSFSPEPGFSLAQLNLI WQLTDTKQLVHSFAEGQDQG SAYANRTALFPDLLAQGNAS LRLQRVRVADEGSFTCFVSI RDFGSAAVSLQVAAPYSKPS MTLEPNKDLRPGDTVTITCS SYQGYPEAEVFWQDGQGVPL TGNVTTSQMANEQGLFDVHS ILRVVLGANGTYSCLVRNPV LQQDAHSSVTITPQRSPTGA VEVQVPEDPVVALVGTDAT |
Additional Info
| Tissue Specificity | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Protein Name | Cd276 Antigen4ig-B7-H3B7 Homolog 3B7-H3Costimulatory MoleculeCd Antigen Cd276 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd276 Antigen protein4ig-B7-H3 proteinB7 Homolog 3 proteinB7-H3 proteinCostimulatory Molecule proteinCd Antigen Cd276 proteinCD276 proteinB7H3 proteinPSEC0249 proteinUNQ309 proteinPRO352 protein |
Information sourced from Uniprot.org