Human B7-H2/ICOSLG/CD275 protein (Recombinant) (C-hFC) (STJP002907)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human B7-H2/ICOSLG/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG/B7-H2/CD275 (Accession #O75144) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human B7-H2/ICOSLG/CD275-C-hFC protein was developed in hek293 cells using the region Asp19-Ser258. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | ICOSLG |
| Gene ID | 23308 |
| Uniprot ID | ICOSL_HUMAN |
| Immunogen | Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG/B7-H2/CD275 (Accession #O75144) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Asp19-Ser258 |
| Immunogen Sequence | KSSPQGPDRLLIRLRHLIDI VEQLKIYENDLDPELLSAPQ DVKGHCEHAAFACFQKAKLK PSNPGNNKTFIIDLVAQLRR RLPARRGGKKQKHIAKCPSC DSYEKRTPKEFLERLKWLLQ KMIHQHLS |
Additional Info
| Tissue Specificity | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). Isoform 1: Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil). Isoform 2: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-9927354 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Protein Names | Icos Ligand proteinB7 Homolog 2 proteinB7-H2 proteinB7-Like Protein Gl50 proteinB7-Related Protein 1 proteinB7rp-1 proteinCd Antigen Cd275 proteinICOSLG proteinB7H2 proteinB7RP1 proteinICOSL proteinKIAA0653 protein |
Information sourced from Uniprot.org