Human B7-DC/PD-L2/CD273 protein (Recombinant) (C-His&Avi) {Biotin} (STJP019816)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human B7-DC/PD-L2/CD273 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Thr220) of Human B7-DC/PD-L2/CD273 (Accession #Q9BQ51) fused with His and Avi tag at the C-te
General Information
| Short Description | Recombinant-Human B7-DC/PD-L2/CD273-C-His&Avi protein was developed in hek293 cells using the region Leu20-Thr220. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | PDCD1LG2 |
| Gene ID | 80380 |
| Uniprot ID | PD1L2_HUMAN |
| Immunogen | Biotinylated Recombinant Human B7-DC/PD-L2/CD273 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Thr220) of Human B7-DC/PD-L2/CD273 (Accession #Q9BQ51) fused with His and Avi tag at the C-te |
| Immunogen Region | Leu20-Thr220 |
| Immunogen Sequence | LFTVTVPKELYIIEHGSNVT LECNFDTGSHVNLGAITASL QKVENDTSPHRERATLLEEQ LPLGKASFHIPQVQVRDEGQ YQCIIIYGVAWDYKYLTLKV KASYRKINTHILKVPETDEV ELTCQATGYPLAEVSWPNVS VPANTSHSRTPEGLYQVTSV LRLKPPPGRNFSCVFWNTHV RELTLASIDLQSQMEPRTHP T |
Additional Info
| Tissue Specificity | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Protein Name | Programmed Cell Death 1 Ligand 2Pd-1 Ligand 2Pd-L2Pdcd1 Ligand 2Programmed Death Ligand 2Butyrophilin B7-DcB7-DcCd Antigen Cd273 |
| Database Links | Reactome: R-HSA-389948 |
| Cellular Localisation | Isoform 3: SecretedIsoform 2: Endomembrane SystemSingle-Pass Type I Membrane ProteinIsoform 1: Cell Membrane |
| Alternative Protein Names | Programmed Cell Death 1 Ligand 2 proteinPd-1 Ligand 2 proteinPd-L2 proteinPdcd1 Ligand 2 proteinProgrammed Death Ligand 2 proteinButyrophilin B7-Dc proteinB7-Dc proteinCd Antigen Cd273 proteinPDCD1LG2 proteinB7DC proteinCD273 proteinPDCD1L2 proteinPDL2 protein |
Information sourced from Uniprot.org