• Biotinylated Human B7-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human B7-1 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Human CTLA-4, hFc Tag at 2 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human B7-1, His Tag with the EC50 of 1. 9 Mu g/ml determined by ELISA.

Human B7-1/CD80 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001714)

SKU:
STJP001714

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human B7-1/CD80-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CD80
Gene ID: 941
Uniprot ID: CD80_HUMAN
Immunogen Region: Val35-Asn242
Immunogen: DNA sequence encoding Human B7-1/CD80 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein Name T-Lymphocyte Activation Antigen Cd80
Activation B7-1 Antigen
Bb1
Ctla-4 Counter-Receptor B7.1
B7
Cd Antigen Cd80
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-389513
Reactome: R-HSA-6783783
Reactome: R-HSA-6811558
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names T-Lymphocyte Activation Antigen Cd80 protein
Activation B7-1 Antigen protein
Bb1 protein
Ctla-4 Counter-Receptor B7.1 protein
B7 protein
Cd Antigen Cd80 protein
CD80 protein
CD28LG protein
CD28LG1 protein
LAB7 protein

Information sourced from Uniprot.org

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