Human B4GALNT2 protein (Recombinant) (N-His) (STJP006398)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human B4GALNT2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | B4GALNT2 |
| Gene ID | 124872 |
| Uniprot ID | B4GN2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr324-Ala566 |
Additional Info
| Function | Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells. |
| Protein Name | Beta-1 -4 N-Acetylgalactosaminyltransferase 2Sd(A Beta-1 -4-Galnac TransferaseUdp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-9037629 |
| Cellular Localisation | Isoform 1: Golgi ApparatusTrans-Golgi Network MembraneSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle MembranePartially Colocalizes With Eea1 And Lamp2 In Early Endosomes And LysosomesRespectivelyIsoform 2: Golgi Apparatus |
| Alternative Protein Names | Beta-1 -4 N-Acetylgalactosaminyltransferase 2 proteinSd(A Beta-1 -4-Galnac Transferase proteinUdp-Galnac -Neu5aca2-3galb-R B1 -4-N-Acetylgalactosaminyltransferase proteinB4GALNT2 proteinGALGT2 protein |
Information sourced from Uniprot.org