Human B3GAT3 protein (Recombinant) (C-His) (STJP014300)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human B3GAT3-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaC, 2mM EDTA, 20% Glycerol, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | B3GAT3 |
| Gene ID | 26229 |
| Uniprot ID | B3GA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu72-Val335 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. |
| Protein Name | Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3Beta-1 -3-Glucuronyltransferase 3Glucuronosyltransferase IGlcat-IUdp-Glcua -Gal Beta-1 -3-Gal-R GlucuronyltransferaseGlcuat-I |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-3560801 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCis-Golgi Network |
| Alternative Protein Names | Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3 proteinBeta-1 -3-Glucuronyltransferase 3 proteinGlucuronosyltransferase I proteinGlcat-I proteinUdp-Glcua -Gal Beta-1 -3-Gal-R Glucuronyltransferase proteinGlcuat-I proteinB3GAT3 protein |
Information sourced from Uniprot.org