Human B29/CD79B protein (Recombinant) (C-His) (STJP001457)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human B29/CD79B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala29-Asp159) of human CD79B (Accession #NP_000617.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human B29/CD79B-C-His protein was developed in hek293 cells using the region Ala29-Asp159. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human CD79B at 0.5 Mu g/mL (100 Mu L/well) can bind CD79B Rabbit mAb with a linear range of 0.1-1.2 ng/mL. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD79B |
| Gene ID | 974 |
| Uniprot ID | CD79B_HUMAN |
| Immunogen | Recombinant Human B29/CD79B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala29-Asp159) of human CD79B (Accession #NP_000617.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Ala29-Asp159 |
| Immunogen Sequence | ARSEDRYRNPKGSACSRIWQ SPRFIARKRGFTVKMHCYMN SASGNVSWLWKQEMDENPQQ LKLEKGRMEESQNESLATLT IQGIRFEDNGIYFCQQKCNN TSEVYQGCGTELRVMGFSTL AQLKQRNTLKD |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |
| Protein Name | B-Cell Antigen Receptor Complex-Associated Protein Beta ChainB-Cell-Specific Glycoprotein B29Ig-BetaImmunoglobulin-Associated B29 ProteinCd Antigen Cd79b |
| Database Links | Reactome: R-HSA-5690714Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinFollowing Antigen BindingThe Bcr Has Been Shown To Translocate From Detergent-Soluble Regions Of The Cell Membrane To Lipid Rafts Although Signal Transduction Through The Complex Can Also Occur Outside Lipid Rafts |
| Alternative Protein Names | B-Cell Antigen Receptor Complex-Associated Protein Beta Chain proteinB-Cell-Specific Glycoprotein B29 proteinIg-Beta proteinImmunoglobulin-Associated B29 Protein proteinCd Antigen Cd79b proteinCD79B proteinB29 proteinIGB protein |
Information sourced from Uniprot.org